Dewaxed and Decarboxylated Medical Cannabis Extract:
Cannabis extract naturally contains neutral, non-active ingredients like waxes and lipids, which do not have much medicinal effect, much focus has been put on producing the cleanest concentrates possible and removing these waxes, particularly for medicinal products destined to be inhaled & taken sublingually. We at Indogenix employ a dewaxing process called winterization which involves, a solvent, usually ethanol, and subsequent cold filtering.
Dewaxed cannabis extract undergoes a heating process which activates Acidic compounds within the extract. This means that it has been through a process called decarboxylation, that means Medical extract or raw cannabis dried bio mass has undergone a chemical process as a result of heating over time. The Raw cannabis extract if prepared in a proven scientific way will certainly contain below detailed out Terpenes, flavinoids, cannabinoids. Just because of the presence of all the Phytochemicals known or unknown, proven scientifically or unproven are definitely present in the extract , But all Plants waxes , Lipids and chlorophyll is removed . Now this extract is referred to as Full spectrum extract still but minus plants waxes and chlorophyll.
Dewaxed cannabis extract contains over 100 cannabinoids. When raw cannabis is analyzed
For its chemical properties, it is found that extract contains CBD & THC in abundant quantity, since larger chunk of CBDA and THCA gets converted into CBD and THC after the extract has gone through decarboxylation process. Sufficient amount of CBG is present too, CBG is the pre stage of CBN.
The Cannabis plant does not directly make CBD or THC. The plant synthesizes cannabinoid acids; such as CBGA, CBDA & CBCA or THCA & THCVA, which must first be activated through the process of decarboxylation to yield the CBD compound. To make the compound more bioavailable to the body and able to interact efficiently with our endocannabinoid system, decarboxylation involves heating the cannabinoid acids into their more accessible forms. After decarboxylation, each of the cannabinoid acids yields their corresponding cannabinoid compound. For example, after the extracted oil goes through decarboxylation, the acid form of CBDA becomes CBD.
CBDA = CBD | CBGA = CBG | CBCA = CBC | THCA = THC
Above process seems simple, but Pharmacists need to be super careful with Exact machinery, and measurement techniques so that While heating the Plant material or the extract the most valuable Flavonoids and other useful components are not lost in air. These minor things make the medicine potent enough to be treated as Medicinal grade medicine.
The cannabis Extract harvested at this stage has high viscosity like honey, the colour of this extract is Golden color if looked through a Glass container through sunlight, and colour seems maroon in the Glass vial.
We at Indogenix Process roughly 50 kilogram of the extract and call it a Batch. The sample from each batch is tested for its contents via a third part Laboratory (the third party laboratory has no stake from Indogenix Biosciences) & one product sample is submitted to Govt. Authorities. Once the report is in, it is crosschecked if there are any heavy metals present, if there is any trace of pesticides etc. If any trace is found Full batch is rejected.
So far we are lucky, never to find any trace of pesticides or fertilizers in the extract , since the Bio mass is sourced from natural spring waters of Parvathy valley and the raw material is actually not manually grown by famers it is grown in the wild, farmers just pluck leaves and supply us raw material via Govt. Agencies involved. And we are super careful inside lab not to use any Bins or machinery having plastic parts. We always use high Grade Steel and borosilicate Glass. Some Of the Machinery is custom made in India, some is imported.
This Cannabis Pure Extract depending upon the Origin of harvest, season, Type of strain leads to two different kinds of cannabinoid profiles. With Experience Our Pharmacists have learnt the cannabinoid profiles of different crops at different times. Cannabinoid profile Extracted from Dried bio mass also depends upon the Tweak in the process of extraction, Our Pharmacists have mustered the art of producing CBD dominant and CBD balanced extracts.
If CBD: THC ratio is 4:1, we call it CBD Dominant, If CBD: THC ratio is 1:1 we refer is to be CBD Balanced. Based on this Cannabinoid profile we have two products available. Since the viscosity of pure extract is very high, it cannot be bottled, as expensive medicine will fail to come out easily while administering to patient, hence a novel method of storage is identified in the form Glass Vials. You just need to remove Front silicone stopper from Vial and press the plunger from behind few drops Come out fairly nicely.
We at Indogenix employ Food grade Ethanol Based Extraction. Ethanol is sourced from Sugar industry and is purely organic and medicinal grade. This Ethanol, is the same alcohol present in alcoholic beverages, produced from the fermentation of yeast and sugars .The relative ease of access, low cost and low flammability make alcohol ideal for extraction. Ethanol extractions will vary in quality and also to the length of time the cannabis is in contact with the solvent.
Short washes (under a minute) will produce a shatter-textured cannabinoid rich extract of high purity containing quite a lot of CBDA and its related compounds , once cold-filtered (winterized), but terpene levels won't be nearly as high as when Cannabis raw material is soaked in Ethanol for extended period of time . So Pharmacists at Indogenix needs to take careful predetermined path chosen after lots of experiments and expertize of scientists involved. The main idea is that extract needs to have all the terpenes present along with sufficient amount of CBD phytochemicals so that the medicine remains potent.