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      CBD and PTSD

      CBD and PTSD
      The ongoing relation between CBD and PTSD (Post Traumatic Stress Disorder), documenting the various forms of conventional treatment methods and the medical trials conducted on subjects suffering from PTSD with CBD.

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      CBD and Depression

       

      History of Depression and Anxiety

      Depression or melancholia has been described earliest in Greece at 300 BCE. It has both genetic and evolutionary causes to manifest

      It has been theorized the growing complexity of the brain causes a vulnerability to depression

      People suffering from depressive disorders find many difficulties in daily life from impairment to lack of motivation as well as painful sensation which trigger depressive thought patterns

      Over the millennia several attempts have been made to treat depression

      While in the ancient times Gautama Buddha experimented with meditation as a means to relieve a person from dukkha (sadness or suffering), since the advent of modern medicine, it is common for prescription drugs such as xanax being prescribed to treat depression

      While there are several pharma and lifestyle options that do help with depression, opiod based medicine carries several risks and has many side effects which have recently caused alarm in societies around the world

      Lifestyle improvement programs such as consistent participation in heavy exercise and healthy diet choices ad well as active social participation definitely help a great deal but it takes a lot of motivation and dedication for a few months before results become visible and trigger a positive thought pattern, this dedication and motivation is often unrealistic to expect out of individuals severely affected by anxiety and depression and hence impaired to a certain degree and already in a negative thought pattern

      Which is why we will be looking at CBD (Cannabidol) as a supplememtary medicine to initiate and develop a healthy lifestyle to achieve long term positive results

      CBD does not carry opiod dependency problems which cause 63000 deaths in the US and addiction problems caused by opiod based prescription medicine

      In this article we will explore the studies conducted, the observational evidence, the science and potential courses of treatment with regards to CBD

      CBD : A Medicinal Overview

      Historically Cannabis has been used as a painkiller in the Greek, Chinese, Indian, Sycthian and Islamic Culture

      Because of the THC content in Cannabis and its sedative effect, it has also been used as an anasthetic agent

      It was only in the 20th century that CBD could be isolated from cannabis

      This bought a new possibility of being able to administer the pain killing and calming properties of cannabis without the 'high' the psychotropic and sedative effect of THC.

      THC is also helpful is treating many conditions which has resulted in legalization of medical marijuana in so many countries however in some cases it has been shown to at times worsen anxiety, cause paranoia and impairment as well as memory loss. 

      The FDA approved a cannaboidol based medicine for treatment of epilepsy

      Cannabis generally has a low percentage of CBD however CBD tinctures have a very highly concentrated and potent dosage of CBD

      Currently millions of people around the world has CBD for its ability to provide relief

      The Research

      Several clinical trials have been conducted since 2014, links for the medical reviews are at the bottom of the this article

      To sum up the conclusions in short,

      Participants were told they were given CBD but only half of the participants were actually given CBD, the other half were given placebos

       80% of the participants in CBD trials responded positively in comparison to 30% in the placebo trials


      Studies show CBD stimulates CB receptors of the endacannaboidal system and triggers a release of dopamine and serotonin

      In comparative studies of CBD and THC, in some cases participants administered THC experienced a worsening in depression symptoms and overall improvement of symptoms of 40% less than patients administered CBD

      Tests were also done on participants suffering from public speaking anxiety and generally positive results were observed


      CBD is currently being researched as a potential medication for a variety of mental health problems and largely the evidence concludes CBD helps

      Several studies on animals showed CBD played a major role in fear memory consolidation. Subjects were able to overcome lab controlled condition activated trauma memories

      This factor may play a huge part in helping people suffering from grief and heartbreak as well as help people overcome social and professional anxiety which would go on to have a positive impact in resolving depression



      Conclusion:

      While there are many theories supporting CBD for its use in mental health ailments, it should be noted that several positive lifestyle habits have to be introduced to a patient alongside CBD treatments to create long term positive effects and encourage mechanisms of dopamine and serotonin release not dependent on any medication

      And at the same time it can be fairly concluded in cases of severe trauma, grief and other incapacitating conditions CBD has the potential to offer relief and reduction in trauma in an extremely short frame of time



      Possible Treatment for Depression using CBD


      We recommend 1mg/kilo dosage

      We also recommended undergoing a multidimensional program for long term improvement, this would include:

      Adopting a non inflammatory and nutritious diet, its important patient gets all required vitamins, fibers, proteins, carbs and fat. Very often deficiencies in nutrition directly correlate with mental health problems

      Exercise: CBD's effect as a painkiller allows individuals to exercise longer as a result of decreased sensitivity to discomfort and pain. This effect should be used as an opportunity to engage in heavy exercise and hence release dopamine and serotonin. Improved body image in the long term also helps in combating anxiety 

      Aroma: Certain aromas such as lemongrass, bergamont are speculated to have positive effects on mental health. The science behind this is that humans at a subconscious level are highly sensitive to smell and smell has been proven to play a huge part in many processes such as partner selection, aggression, etc as it directly interacts with the neural pathways

      Sound: Experiments conducted on animals conclude that pleasant music increases activity and overall traits associated with happiness. It is recommended to listen to positive motivational and encouraging music as much as you can throughout the day on low volumes with an underlying intention of changing thought narrative to a positive one

      Visual positive stimuli: being surrounded by positive colors, positive quotes and images definitely plays a role in reinforcing positive thought patterns

      We believe the combination of all these can definitely help an individuals fight against depression and anxiety

      Sources:

      https://cbd-b.be/wp-content/uploads/2018/09/2014-Antidepressant-Like-and-Anxiolytic-Like-Effects-of-Cannabidiol.pdf

       

      https://www.ncbi.nlm.nih.gov/m/pubmed/24923339/

       

      https://link.springer.com/article/10.1007/s13311-015-0387-1










      CBD and Epilepsy

      Epilepsy is a central nervous system (neurological) disorder in which brain activity becomes abnormal, causing seizures or periods of unusual behavior, sensations, and sometimes loss of awareness.

      Epilepsy is the fourth most common neurological disorder and affects people of all ages.

      Although the symptoms of a seizure may affect any part of the body, the electrical events that produce the symptoms occur in the brain. The location of that event, how it spreads, how much of the brain is affected, and how long it lasts all have profound effects. These factors determine the character of a seizure and its impact on the individual.

      Epilepsies are classified as:

      • generalized epilepsy – The seizures affect both sides of the brain. These seizures    affect awareness of the patient, stiffening and jerking of muscles.
      • focal epilepsy – In focal epilepsy, the seizures start in one region of the brain and it may spread to other regions of the brain. In these types of seizures the patient may not be able to talk, may act vague, confused or disoriented
      • combined generalized and focal epilepsy – The symptoms include a combination of generalized and focal epilepsy.
      • unknown epilepsy – These seizures cannot be diagnosed as either focal or generalized seizures

      History
      Epilepsy was earlier thought to be a spiritual condition.     In the world’s earliest description of an epilepsy episode, the person was thought to be under the influence of a moon god and underwent an exorcism. Throughout ancient times due to the uncertainty they were dealing with people often attributed the seizures to being possessed by evil spirits.

      A breakthrough came when Hippocrates in his work On the Sacred Disease proposed that epilepsy was not divine in origin but a medically treatable problem in the brain. As one might wonder there was a lot of absurdity surrounding the condition, it was even reported people used to spit on the chest of people believing that it would help the problem from affecting them.

      Diagnosis
      Modern medicine has made it possible for us to better understand the inner workings of epilepsy. Through methods like EEG, CT scan and MRI scans it has been understood that when diagnosing patients we have to look for abnormal brain wave patterns. These abnormal brain wave patterns correlate with the seizures that patients experience.

      Statistics
      According to a recent study there are 70 million people with epilepsy worldwide and 90% of them are from developing countries of which 35 million are from Asia and nearly 12 million people are expected to reside in India.

      Medication
      The treatment of epilepsy is mainly based on prescribing antiseizure medications to the patient. These antiseizure medicines act as mood stabilizers for patients. 

      CBD
      While CBD is a component of marijuana (one of hundreds), by itself it does not cause a “high.” According to a report from the World Health Organization, “In humans, CBD exhibits no effects indicative of any abuse or dependence potential…. To date, there is no evidence of public health related problems associated with the use of pure CBD.

      CBD has been touted for a wide variety of health issues, but the strongest scientific evidence is for its effectiveness in treating some of the cruelest childhood epilepsy syndromes, such as Dravet syndrome and Lennox-Gastaut syndrome (LGS), which typically don’t respond to antiseizure medications. In numerous studies, CBD was able to reduce the number of seizures, and in some cases it was able to stop them altogether


      Trials conducted

      The researchers found that a single injection of CBD substantially lessened seizure severity in mice when the seizures were experimentally triggered by elevated body temperature or loud sounds. A typical anti-convulsant dose of CBD (100 mg/kg) caused mild sedation in mice but had little effect on motor coordination or balance. CBD also restored the normal brain rhythms which are commonly impaired in Angelman syndrome.

      In a year-long study conducted by epilepsy specialists at the New York University Langone Medical Center, results have suggested that CBD, a derivative of medical marijuana effectively reduces seizure frequency and is safe for most children and young adults who have epilepsy.

      For the randomized, double-blind, placebo-controlled study, researchers followed 225 people with an average age of 16 for 14 weeks. The participants had an average of 85 drop seizures per month, had already tried an average of six epilepsy drugs that did not work for them and were taking an average of three epilepsy drugs during the study.

      Participants were given either a higher dose of 20 mg/kg daily cannabidiol, a lower dose of 10 mg/kg daily cannabidiol or placebo as an add-on to their current medications for 14 weeks.

      Those taking the higher dose had a 42 percent reduction in drop seizures overall, and for 40 percent, their seizures were reduced by half or more.

      Those taking the lower dose had a 37 percent reduction in drop seizures overall, and for 36 percent, seizures were reduced by half or more.

      Those taking the placebo had a 17 percent reduction in drop seizures, and for 15 percent, seizures were reduced by half or more.

      Nearly 40 percent of people with LGS, which starts in childhood, had at least a 50 percent reduction in drop seizures when taking a liquid form of cannabidiol compared to 15 percent taking a placebo.

      Conclusion:

      While there is a lot more research that needs to be done, we can say that CBD has shown to be an effective treatment for epilepsy with research done so far

      It is important to note that subjects were generally healthy and were on an anti inflammation diet, which helped in the positive outcomes of the subjects health

      So it is suggested the pain killing effects of CBD could be used to introduce an exercise and nutrition routine