Fisetin  flavonoid exhibits a wide variety of activities, including neurotrophic , anti-oxidant , anti-inflammatory , and anti-angiogenic  activities. Fisetin has shown efficacy against numerous cancer types including prostate cancer, liver cancer, colon cancer , and leukaemia. Fisetin has also been shown to possess anti-inflammatory activity. Fisetin has also shown potential against other chronic diseases. For example, in ovalbumin-induced asthma, fisetin attenuated lung inflammation and airway hyper-responsiveness and decreased eosinophils and lymphocytes in bronchoalveolar fluid. Fisetin reduced the expression of the key initiators of allergic airway inflammation (eotaxin-1 and TSLP), Th2-associated cytokines (IL-4, IL-5, and IL-13) in lungs, and Th2-predominant transcription factor GATA-3 and cytokines in thoracic lymph node cells and splenocytes. This flavonoid has shown cardioprotective properties. 

Chemoprevention is an emerging, appealing, and an innovative strategy for the management of cancer. While fruits and vegetables are an abundant source of many cofactors, vitamins, minerals, the phytochemicals constituents known as flavonoids have special ability to target several key cellular events involved in the development of cancer.  Flavonoids are the most abundant polyphenols consumed in human diet and are classified into flavonols, flavones, isoflavones, anthocyanidins, theaflavins, and thearubigins. Several studies have demonstrated that flavonoids possess anti-oxidant, anti-inflammatory, and chemopreventive properties. The compound tetrahydroxyflavone is a natural flavone commonly referred to fisetin.  Major fisetin containing food sources include strawberries, apples, persimmons, grapes, onions, and cucumbers  as shown in. Fisetin affects multiple molecular and signaling pathways depending on the cancer type . Among all the multiple biological effects fisetin possesses, its anticancer potential has been recently explored making it a promising agent for cancer prevention and therapy. This review summarizes the cellular effects of fisetin in an attempt to elucidate its preventive and therapeutic potential against various cancers.

Fisetin interacts with multiple cellular targets by binding to and interacting with several molecular targets fisetin regulates a wide variety of cell functions. Fisetin disrupts Wnt signaling and results in cell cycle arrest. It inhibits the YB-1 binding protein to suppress epithelial to mesenchymal transition and thus prevents invasion and migration of cancer cells. By physically interacting with the mTOR molecule, fisetin inhibits signaling involved in cell survival thus explaining its inhibitory effect on cellular growth and proliferation. Fisetin binds to and disrupts microtubule dynamics and acts as a stabilizing agent with effects far superior to paclitaxel. However across all cancers, mTOR and NF-kB appear to be the most commonly affected pathways.

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